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TEPEZZA is an intravenous (IV) medicine. This means it is delivered through a needle that is placed in your arm. IV medicines like TEPEZZA are most often given by a registered nurse (RN), nurse practitioner (NP), or another medical professional. The process of delivering an intravenous, or "IV," medicine is called an infusion.
How TEPEZZA (teprotumumab-trbw) works to treat Thyroid Eye Disease, or TED.
TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease (TED), no matter if you’ve had TED for months or years.
TEPEZZA may cause infusion reactions. Tell your doctor right away if you have high blood pressure, fast heartbeat, redness of the face or feeling hot, difficulty breathing, headache, or muscle pain.
Please stay tuned for additional Important Safety Information later in this video.
Thyroid Eye Disease, or TED, is a serious vision threatening condition. You may have heard Thyroid Eye Disease called Graves’ eye disease.
To understand what causes TED, you have to go behind the eye.
In the tissue behind the eye are cells which have receptors on their surface that act like switches. But when you have TED, your body’s immune system attacks this tissue, which causes molecules, known as autoantibodies, to turn these switches on. This leads to swelling of the muscle and fat.
The swollen muscle and fat tissue behind the eye can also make the eyes bulge, which your doctor may call proptosis and cause double vision which your doctor may call Diplopia.
TEPEZZA is the first FDA-approved treatment for Thyroid Eye Disease.
TEPEZZA treats a source of TED, not just the symptoms.
While precisely how TEPEZZA works is not fully understood. TEPEZZA is designed to bind to the switch and block it from turning on.
Since TEPEZZA blocks the switches so they cannot turn on, swelling of the muscle and fat tissue goes down.
This can lead to reduced bulging of the eyes.
TEPEZZA can also improve double vision, and in some cases make it completely go away.
Please keep watching to hear Important Safety Information about TEPEZZA.
Talk to your doctor about TEPEZZA.
TEPEZZA treatment includes 8 infusions, one given every 3 weeks.
Your first and second infusions of TEPEZZA will last about 90 minutes each. Your remaining 6 infusions will take about 60 minutes each, but could be longer depending on how you react to the infusion.
The amount of TEPEZZA that you will receive during each infusion is based on how much you weigh at the time and will be determined by your doctor.
This is the dosing schedule as prescribed for a patient who reacts well to the initial 2 infusions.
Real patients talk about how they felt before, during and after their infusions.
Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.
TEPEZZA may worsen inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, even if you don’t have a diagnosis of IBD before starting TEPEZZA treatment. Tell your doctor right away if you have worsening IBD symptoms, which may include diarrhea with stomach pain or cramps, blood in your stools, sudden urgency to have a bowel movement, or feeling like you need to have a bowel movement even when there’s little or no stool to pass.
TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.
TEPEZZA may cause severe hearing problems including hearing loss, which in some cases may be permanent. Tell your doctor if you have any signs or symptoms of hearing problems or changes in hearing.
The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, ear discomfort, weight loss, nail problems, and changes in menstruation.
This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.
TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease (TED), no matter if you’ve had TED for months or years.
Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.
