How TEPEZZA Can Help Thyroid Eye Disease (TED)

Whether you’re newly diagnosed or have had Thyroid Eye Disease (TED) for years, TEPEZZA could help

Thyroid Eye Disease (TED) is a lifelong, autoimmune condition that affects the eyes. If TED is left untreated, scar tissue can build up behind the eye, causing damage, which could become permanent. TEPEZZA is the first and only FDA-approved medicine to treat TED, no matter if you’ve had TED for months or years. And TEPEZZA treats a source of TED, not just the symptoms.

I have been recently diagnosed
Reduce eye bulging and look more like yourself again

*Eye bulging was reduced by at least 2 mm.

You could see results as early as 6 weeks

With TEPEZZA, some people began to see less eye bulging in as few as 6 weeks, with improvements continuing for the full course of 8 infusions. No one took steroids during their treatment

Real results with TEPEZZA

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Real patients treated with TEPEZZA in a clinical study. Individual results may vary.

See more clearly by improving double vision

^†Two studies were conducted throughout 24 weeks each, and followed patients taking TEPEZZA who were recently diagnosed with moderate-to-severe TED.

Get multi-symptom relief from eye pain, redness, and swelling

In clinical studies, 2 out of 3 people who completed treatment with TEPEZZA had little to no:

Eye Pain including pain behind the eye and when moving the eye

Redness of the eye and eyelid

Swelling of the eye and eyelid

In combined results from two studies, TED patients’ levels of inflammation were recorded using their Clinical Activity Score (CAS), which is a tool that doctors use to assess their patients’ TED symptoms. It evaluates for the presence of 7 symptoms in the eyes and surrounding area: pain that happens for no apparent reason; pain due to looking at something for too long; eyelid swelling; eyelid redness; redness of the eye itself; swelling of the eye, and inflammation in the inner corner of the eye. The higher the CAS number (from 0 to 7), the more serious the impact of TED is seen to be.

In patients with a CAS of at least 4 at the start of treatment, by the end of treatment 62% (52 of 84) of those treated with TEPEZZA had a CAS of 0 or 1 (seen as inactive disease state) compared to 22% (18 of 87) of those who were treated with placebo.

Each of the 7 symptoms is counted equally toward a single overall score, even though that may not reflect their impact to the individual patient. For example, if a patient has eye redness and eye pain, but is only really bothered by the eye pain, each symptom still adds to the overall score by 1.

See the latest study on how TEPEZZA can treat TED even if you’ve had it for years.
I have had TED for years
A recent study shows TEPEZZA is proven to help patients who were diagnosed with TED years ago

*Eye bulging was reduced by at least 2 mm.

All patients in the 24-week study

had TED for 2 to 10 years

experienced eye bulging

didn’t have symptom changes for at least a year prior

Real results with TEPEZZA

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Real patients treated with TEPEZZA in a clinical study. Individual results may vary.

Kim E. struggled with TED for more than 25 years before taking TEPEZZA

Watch her story

I have been recently diagnosed
I have had TED for years

Reduce eye bulging and look more like yourself again

Graphic of statistic that 7 out of 10 people taking TEPEZZA saw their double vision improve

*Eye bulging was reduced by at least 2 mm.

You could see results as early as 6 weeks

With TEPEZZA, some people began to see less eye bulging in as few as 6 weeks, with improvements continuing for the full course of 8 infusions. No one took steroids during their treatment

Real results with TEPEZZA

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Real patients treated with TEPEZZA in a clinical study. Individual results may vary.

See more clearly by improving double vision

Graphic of statistic that 5 out of 10 people taking TEPEZZA saw their double vision completely go away

^†Two studies were conducted throughout 24 weeks each, and followed patients taking TEPEZZA who were recently diagnosed with moderate-to-severe TED.

Get multi-symptom relief from eye pain, redness, and swelling

In clinical studies, 2 out of 3 people who completed treatment with TEPEZZA had little to no:

Eye Pain including pain behind the eye and when moving the eye

Redness of the eye and eyelid

Swelling of the eye and eyelid

In combined results from two studies, TED patients’ levels of inflammation were recorded using their Clinical Activity Score (CAS), which is a tool that doctors use to assess their patients’ TED symptoms. It evaluates for the presence of 7 symptoms in the eyes and surrounding area: pain that happens for no apparent reason; pain due to looking at something for too long; eyelid swelling; eyelid redness; redness of the eye itself; swelling of the eye, and inflammation in the inner corner of the eye. The higher the CAS number (from 0 to 7), the more serious the impact of TED is seen to be.

In patients with a CAS of at least 4 at the start of treatment, by the end of treatment 62% (52 of 84) of those treated with TEPEZZA had a CAS of 0 or 1 (seen as inactive disease state) compared to 22% (18 of 87) of those who were treated with placebo.

Each of the 7 symptoms is counted equally toward a single overall score, even though that may not reflect their impact to the individual patient. For example, if a patient has eye redness and eye pain, but is only really bothered by the eye pain, each symptom still adds to the overall score by 1.

See the latest study on how TEPEZZA can treat TED even if you’ve had it for years.

A recent study shows TEPEZZA is proven to help patients who were diagnosed with TED years ago

Graphic of statistic that 6 out of 10 people taking TEPEZZA saw reduced eye bulging

*Eye bulging was reduced by at least 2 mm.

All patients in the 24-week study

had TED for 2 to 10 years
experienced eye bulging
didn’t have symptom changes for at least a year prior

Real results with TEPEZZA

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Before TEPEZZA

After Treatment (Week 24)

Real patients treated with TEPEZZA in a clinical study. Individual results may vary.

Hear from real TEPEZZA patients who experienced success with treatment

Kim E., real TEPEZZA patient, diagnosed with TED in 1993

Watch Kim’s Story
Jeanne T., real TEPEZZA patient diagnosed with TED in 2019

Watch Jeanne’s Story
Randi C., real TEPEZZA patient diagnosed with TED in 2020

Watch Randi’s Story

Individual results may vary.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:

High blood pressure
Fast heartbeat
Redness of the face/Feeling hot

Difficulty breathing
Headache
Muscle pain

TEPEZZA may worsen inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, even if you don’t have a diagnosis of IBD before starting TEPEZZA treatment. Tell your doctor right away if you have worsening IBD symptoms, which may include diarrhea with stomach pain or cramps, blood in your stools, sudden urgency to have a bowel movement, or feeling like you need to have a bowel movement even when there’s little or no stool to pass.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

TEPEZZA may cause severe hearing problems including hearing loss, which in some cases may be permanent. Tell your doctor if you have any signs or symptoms of hearing problems or changes in hearing.

Before receiving TEPEZZA, tell your doctor if you:

Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
- Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, ear discomfort, weight loss, nail problems, and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information or visit TEPEZZA.com for more information.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease (TED), no matter if you’ve had TED for months or years.

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How TEPEZZA Can Help Thyroid Eye Disease (TED)

Whether you’re newly diagnosed or have had Thyroid Eye Disease (TED) for years, TEPEZZA could help

Reduce eye bulging and look more like yourself again

You could see results as early as 6 weeks

Real results with TEPEZZA

See more clearly by improving double vision

Get multi-symptom relief from eye pain, redness, and swelling

In clinical studies, 2 out of 3 people who completed treatment with TEPEZZA had little to no:

A recent study shows TEPEZZA is proven to help patients who were diagnosed with TED years ago

Real results with TEPEZZA

Kim E. struggled with TED for more than 25 years before taking TEPEZZA

Reduce eye bulging and look more like yourself again

You could see results as early as 6 weeks

Real results with TEPEZZA

See more clearly by improving double vision

Get multi-symptom relief from eye pain, redness, and swelling

In clinical studies, 2 out of 3 people who completed treatment with TEPEZZA had little to no:

A recent study shows TEPEZZA is proven to help patients who were diagnosed with TED years ago

Real results with TEPEZZA

Kim E. struggled with TED for more than 25 years before taking TEPEZZA

Find a TED Specialist

Hear from real TEPEZZA patients who experienced success with treatment

Have questions about TEPEZZA financial support?

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:

Before receiving TEPEZZA, tell your doctor if you:

What are the possible side effects of TEPEZZA?

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information or visit TEPEZZA.com for more information.

USE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?