Thyroid Eye Disease Symptoms

Bulging eyes and other TED symptoms

Thyroid Eye Disease (TED) can cause a number of different symptoms. You may notice some symptoms develop slowly and others appear quickly.

Once TED reaches the non-progressive (or "inactive") phase, damage may become permanent. So, it is important to recognize symptoms early and start a treatment plan with your doctor. The sooner you spot changes to your eyes, the sooner your doctor can help.

Bulging eyes

Although there are many symptoms of TED to look out for, bulging of the eye is one of the most common and noticeable.

Real pictures of bulging eyes

During the progressing (or “active”) phase of TED, the eyeball may bulge forward in one eye or both eyes. You may hear your doctor call this symptom proptosis (prop-toe-sis) or exophthalmos (ek-sof-thal-muhs).

Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket

Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket

Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket Front view of bulging eyes protruding from the eye socket, Side view of bulging eyes protruding from the eye socket

What causes bulging eyes?

During progressing (or "active") TED, muscle and fat tissue behind the eyes become swollen. This swelling can push against the back of the eye, causing it to bulge forward.

How are bulging eyes measured?

During an eye exam, your doctor will use a special ruler called an exophthalmometer (ek-sof-thuhl-mom-i-ter) to measure how far the eyes have bulged.

Generally, your doctor will measure eye bulging before, during, and after treatment. This way, they can keep track of how much your eyes have improved.


Other symptoms of Thyroid Eye Disease to look for

TED affects everyone differently. You may experience all or some of the following symptoms:

Pulled-back eyelid icon Pulled-back eyelid icon Pulled-back eyelid icon

Pulled-back eyelid, also called eyelid retraction

  • Eyelids are pulled back or retracted
  • This may cause a constant stare or wide-eyed appearance
  • It may also make it hard to close your eyes
  • To sleep, your eyes may need to be taped shut
Swollen, puffy eyelids icon Swollen, puffy eyelids icon Swollen, puffy eyelids icon

Swollen, puffy eyelids

  • Eyelids look red and swollen
  • Your doctor may call this eyelid edema (ih-dee-muh)
Dry, gritty eyes icon Dry, gritty eyes icon Dry, gritty eyes icon

Dry, gritty eyes

  • Eyes feel dry and gritty
  • This may make it feel like there’s something in your eye, like sand
Red, swollen eyes icon Red, swollen eyes icon Red, swollen eyes icon

Red, swollen eyes

  • Eyes appear red, bloodshot, and swollen
  • Your doctor may call this erythema (er-uh-thee-muh) or chemosis (key-moe-sis)
  • This is sometimes confused with allergies or an infection
Watery, teary eyes icon Watery, teary eyes icon Watery, teary eyes icon

Watery, teary eyes

  • Eyes are constantly watery, when not crying
  • This can make it hard to see clearly because of extra fluid
Eye pain or pressure icon Eye pain or pressure icon Eye pain or pressure icon

Eye pain or eye pressure

  • Pain may be felt in, around and behind the eyes, and when moving the eyes
  • Pressure may be felt behind or around the eyes, which can lead to headaches
Light sensitivity icon Light sensitivity icon Light sensitivity icon

Light sensitivity

  • Eyes become very sensitive to light
  • Your doctor may call this photophobia (foh-tuh-foh-bee-uh)
Misaligned eyes icon Misaligned eyes icon Misaligned eyes icon

Misaligned eyes

  • Eyes look crossed or misaligned
  • This can lead to double vision
  • Your doctor may call this strabismus (struh-biz-muhs)
Blurry vision icon Blurry vision icon Blurry vision icon

Blurry vision

  • Vision becomes out of focus or blurry
Double vision icon of two eyes merged on top of each other Double vision icon of two eyes merged on top of each other Double vision icon of two eyes merged on top of each other

Double vision

  • One image will look like 2
  • Your doctor may call this diplopia (dih-ploh-pee-uh)
  • Double vision can be:
    • Temporary (for example, upon waking up in the morning)
    • Situational (for example, when looking to the left or right, or toward the corners of the eyes)
    • Constant (always present)

See how these different types of double vision look

Color vision loss icon Color vision loss icon Color vision loss icon

Color vision loss

  • Colors look dull or washed out
  • In rare cases, all color vision may be lost

Changes to color vision could mean your sight is at risk. If you notice color vision changes, talk to your doctor right away.

Vision loss icon Vision loss icon Vision loss icon

Vision loss

  • In rare cases, blindness may occur

If you notice any vision loss, talk to your doctor right away.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.