Patients who Had TED for Years Before and After TEPEZZA Treatment

Real-world cases have shown that TEPEZZA can work in patients who have had TED for up to 20 years

TEPEZZA results in real-world patients who had TED for years from one published case series:

A small study of 31 patients who had TED for years was done across several university hospitals.

  • On average the patients who were in this study had TED for 7 years (ranging from 2 to 17 years)

At the time the study was published, 17 of these patients had completed all 8 infusions of TEPEZZA. The remaining 14 patients were in the process of finishing treatment.

The results of the study showed:

  • All 31 patients with chronic TED had eye bulging before taking TEPEZZA. After TEPEZZA, 28 of the 31 chronic patients saw reduced eye bulging* in their more severe eye
  • 15 of the 31 patients with chronic TED had double vision before taking TEPEZZA. After TEPEZZA, 10 of the 15 chronic patients saw improvements in double vision. And 8 of the 15 patients saw their double vision completely go away
  • All 31 patients with chronic TED had redness, swelling and eye pain before taking TEPEZZA. After TEPEZZA, 28 of the 31 chronic patients had little to no redness, swelling, and eye pain. And 18 of the 31 patients had their redness, swelling, and eye pain completely go away

*Eye bulging was reduced by at least 2 mm

Before and After TEPEZZA photos of patients who had Thyroid Eye Disease for years. Patients saw reduced eye bulging, redness, and swelling:

Comparison photos of patient with Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing reduced eye bulging after 8 infusions Comparison photos of patient with Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing reduced eye bulging after 8 infusions

Before TEPEZZA

  • Before TEPEZZA, this patient had eye bulging, double vision, and mild eye redness, swelling, and pain
  • His prior treatments were steroids, radiation, decompression eye surgery, and strabismus eye surgery

Comparison photos of patient with Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing reduced eye bulging after 8 infusions

After Treatment (8 infusions)

  • After TEPEZZA, this patient had reduced eye bulging of 6 mm in one eye and 4.5 mm in the other eye. His double vision, eye pain, redness, and swelling completely went away

Real patient treated with TEPEZZA. Individual results may vary.

Select Important Safety Information

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, weight loss, nail problems, and changes in menstruation.

See how TEPEZZA works

TEPEZZA is the only medicine to treat Thyroid Eye Disease (TED) at its source, not just the symptoms. Watch a video to see how TEPEZZA treats TED.

TEPEZZA Reduced Eye Bulging: results from another real-world study of patients who had TED for years

Another small study of 9 patients who had TED for years was done at the Shiley Eye Institute located at the University of California, San Diego.

  • On average, the patients in the study had TED for 6 years (ranging from 9 months to 20 years)

All patients in the study completed all 8 infusions of TEPEZZA.

The results of the study showed:

  • 7 out of the 9 patients with chronic TED taking TEPEZZA had reduced eye bulging*
  • Although only 3 of the 9 patients with chronic TED had inflammation (eye pain, redness, and swelling) before they started TEPEZZA, all 3 of these patients had little-to-no redness, swelling, and eye pain after taking TEPEZZA

*Eye bulging was reduced by at least 2 mm

Select Important Safety Information

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Talking to your doctor about Thyroid Eye Disease

Use this tool to help your TED Eye Specialist better understand the full impact of TED on your daily life.

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More photos of Thyroid Eye Disease before and after TEPEZZA treatment

Below are photos that doctors took of some patients who had TED for years before TEPEZZA and after 8 infusions. Individual results may vary.

Before TEPEZZA

Comparison photos of patient with Chronic Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing less eyelid retraction after 8 infusionsComparison photos of patient with Chronic Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing less eyelid retraction after 8 infusions

After Treatment (8 infusions)

Real patient treated with TEPEZZA. Individual results may vary.

Before receiving TEPEZZA, this patient had multiple surgeries, including:

  • A thyroidectomy (removal of the thyroid)
  • Decompression surgery (to reduce eye bulging)
  • Lower lid retraction repair surgeries (to repair pulled-back eyelids)
  • Surgery to restore the appearance of her face and eyes

Despite these treatments and surgery, the patient still had eye bulging before TEPEZZA.

Before TEPEZZA

Photos of patient with Chronic Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing reduced eye bulging after 8 infusionsPhotos of patient with Chronic Thyroid Eye Disease before and after TEPEZZA treatment, with post-treatment photo showing reduced eye bulging after 8 infusions

After Treatment (8 infusions)

Real patient treated with TEPEZZA. Individual results may vary.

Before receiving TEPEZZA, this patient was treated with:

  • Steroids taken by mouth
  • Steroid injections
  • Surgery to reduce eye bulging

Despite these treatments and surgery, the patient still had double vision and eye bulging before TEPEZZA.

A study shows TEPEZZA can help patients who have had TED for years

See how TEPEZZA can help a wide range of TED patients.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

TEPEZZA may cause severe hearing problems including hearing loss, which in some cases may be permanent. Tell your doctor if you have any signs or symptoms of hearing problems or changes in hearing.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, weight loss, nail problems, and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.
Please visit TEPEZZA.com for more information.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease (TED), no matter if you’ve had TED for months or years.

P-TEP-US-00841-3 07/23

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

TEPEZZA may cause severe hearing problems including hearing loss, which in some cases may be permanent. Tell your doctor if you have any signs or symptoms of hearing problems or changes in hearing.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin, weight loss, nail problems, and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.
Please visit TEPEZZA.com for more information.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease (TED), no matter if you’ve had TED for months or years.

P-TEP-US-00841-3 07/23