TEPEZZA Use in Chronic Thyroid Eye Disease

There are real-world cases that show use of TEPEZZA in patients with chronic Thyroid Eye Disease (TED)

Information about one published case series of TEPEZZA use in patients with chronic TED:

A small study of 31 patients with chronic Thyroid Eye Disease (TED) was done across several university hospitals.

  • On average, the patients who were in this study had TED for 7 years (ranging from 2 to 17 years)

At the time the study was published, 17 of these patients had completed all 8 infusions of TEPEZZA. The remaining 14 patients were in the process of finishing treatment.

The results of the study showed:

  • All 31 patients with chronic TED had eye bulging before taking TEPEZZA. After TEPEZZA, 28 of the 31 chronic patients saw reduced eye bulging* in their more severe eye
  • 15 of the 31 patients with chronic TED had double vision before taking TEPEZZA. After TEPEZZA, 10 of the 15 chronic patients saw improvements in double vision. And 8 of the 15 patients saw their double vision completely go away
  • All 31 patients with chronic TED had redness, swelling and eye pain before taking TEPEZZA. After TEPEZZA, 28 of the 31 chronic patients had little to no redness, swelling, and eye pain. And 18 of the 31 patients had their redness, swelling, and eye pain completely go away

*Eye bulging was reduced by at least 2 mm

Take a look at the photos below to see how TEPEZZA helped the eye bulging, redness, and swelling of one patient with chronic TED:

Chronic Thyroid Eye Disease patient before TEPEZZA with eye bulging, double vision, mild redness, swelling, and pain Chronic Thyroid Eye Disease patient before TEPEZZA with eye bulging, double vision, mild redness, swelling, and pain Chronic Thyroid Eye Disease patient before TEPEZZA with eye bulging, double vision, mild redness, swelling, and pain

Before TEPEZZA

  • Before TEPEZZA, this patient had eye bulging, double vision, and mild eye redness, swelling, and pain
  • His prior treatments were steroids, radiation, decompression eye surgery, and strabismus eye surgery
Chronic Thyroid Eye Disease patient after eight TEPEZZA infusions Chronic Thyroid Eye Disease patient after eight TEPEZZA infusions Chronic Thyroid Eye Disease patient after eight TEPEZZA infusions

After Treatment (8 infusions)

  • After TEPEZZA, this patient had reduced eye bulging of 6 mm in one eye and 4.5 mm in the other eye. His double vision, eye pain, redness, and swelling completely went away

Real patient treated with TEPEZZA. Individual results may vary.

Select Important Safety Information

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin and changes in menstruation.

In another study of TEPEZZA used in patients with chronic TED:

Another small study of 9 patients with chronic TED was done at the Shiley Eye Institute located at the University of California, San Diego.

  • On average, the patients in the study had TED for 6 years (ranging from 9 months to 20 years)

All patients in the study completed all 8 infusions of TEPEZZA.

The results of the study showed:

  • 7 out of the 9 patients with chronic TED taking TEPEZZA had reduced eye bulging*
  • Although only 3 of the 9 patients with chronic TED had inflammation (eye pain, redness, and swelling) before they started TEPEZZA, all 3 of these patients had little-to-no redness, swelling, and eye pain after taking TEPEZZA

*Eye bulging was reduced by at least 2 mm

Select Important Safety Information

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Patient photos of chronic Thyroid Eye Disease before and after TEPEZZA treatment

Below are some photos that doctors have taken of real patients with chronic TED before TEPEZZA and after 8 infusions. Individual results may vary.

Before TEPEZZA

Chronic Thyroid Eye Disease patient with bulging eyes before starting TEPEZZA

After Treatment (8 infusions)

Chronic Thyroid Eye Disease patient after eight TEPEZZA infusions

Real patient treated with TEPEZZA. Individual results may vary.

Before receiving TEPEZZA, this patient had multiple surgeries, including:

  • A thyroidectomy (removal of the thyroid)
  • Decompression surgery (to reduce eye bulging)
  • Lower lid retraction repair surgeries (to repair pulled-back eyelids)
  • Surgery to restore the appearance of her face and eyes

Despite these treatments and surgery, the patient still had eye bulging and some changes in facial appearance before TEPEZZA.

Before TEPEZZA

Chronic Thyroid Eye Disease patient with bulging eyes before first TEPEZZA infusion

After Treatment (8 infusions)

Chronic Thyroid Eye Disease patient after eight TEPEZZA infusions

Real patient treated with TEPEZZA. Individual results may vary.

Before receiving TEPEZZA, this patient was treated with:

  • Steroids taken by mouth
  • Steroid injections
  • Surgery to reduce eye bulging

Despite these treatments and surgery, the patient still had eye bulging and some changes in facial appearance before TEPEZZA.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.
Please visit TEPEZZA.com for more information.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, dry skin and changes in menstruation.

This is not a complete list of all possible side effects. Tell your doctor or treatment team about any side effect you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.
Please visit TEPEZZA.com for more information.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.