TEPEZZA has Resumed Production and is Now Available

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Was your scheduled TEPEZZA treatment interrupted?

Now is the time to get started again!

In December 2020, Horizon Therapeutics, developer of TEPEZZA, announced a short-term disruption in the supply of TEPEZZA. This disruption was a result of recent COVID-19 vaccine production orders required by the government. This required that the manufacturing facility for TEPEZZA, Catalent, make the COVID-19 vaccine instead of TEPEZZA. This was not Horizon’s choice. We know that this interruption of your treatment was frustrating. Your eye health is important and, now that TEPEZZA is available again, don’t delay your treatment! Talk to your doctor about your plan to resume treatment and then share that plan with your infusion center. You can contact your infusion center directly to schedule your next infusion or call a Patient Access Manager (PAM) if you need help with the process of resuming treatment.

Many patients have been affected by this disruption and we are doing all that we can to make this process as seamless as possible, but there may be delays depending on your individual situation. Your infusion center can also let you know their availability for your next TEPEZZA infusion.

To make the most out of your TEPEZZA treatment, all 8 infusions are recommended

In clinical studies with TEPEZZA, the majority of people who completed all 8 infusions had:

eye-bulging

Reduced eye bulging

double-vision

Improved double vision

eye-pain

Less eye pain, redness, and swelling

Physical appearance icon

Improved physical appearance and visual ability

Take a look at the graph below to see how eye bulging was reduced in patients taking TEPEZZA in clinical studies. Some patients began to see less eye bulging in as few as 6 weeks, with improvements continuing for the full course of all 8 infusions. So keep on going!

Most patients continued to see improvements through all 8 infusions
Graph displaying results in patients treated with TEPEZZA, in a clinical setting, after 8 infusions Graph displaying results in patients treated with TEPEZZA, in a clinical setting, after 8 infusions Graph displaying results in patients treated with TEPEZZA, in a clinical setting, after 8 infusions

*Patients A and B are real patients treated with TEPEZZA in a clinical study. Individual results may vary. 8 out of 10 patients had at least 2 mm improvement in one eye without worsening in the other.

Ready to get started with TEPEZZA?

In December 2020, Horizon Therapeutics, developer of TEPEZZA, announced a short-term disruption in the supply of TEPEZZA. This disruption was a result of recent COVID-19 vaccine production orders required by the government. This required that the manufacturing facility for TEPEZZA, Catalent, make the COVID-19 vaccine instead of TEPEZZA. This was not Horizon’s choice. We know that this was a frustrating time. Your eye health is important and, now that TEPEZZA is available again, don’t delay your treatment! Talk to your doctor about starting your treatment. If you need help with the process of starting TEPEZZA, connect with a Patient Access Manager (PAM). A PAM can help you:

Find out if your insurance provider has approved your TEPEZZA treatment. A PAM can let you know where you stand in the approval process

Schedule your first infusion, if your treatment has been approved

If you already have an infusion center, you can also contact them for more information.

Many patients have been affected by this disruption and we are doing all that we can to make this process as seamless as possible, but there may be delays depending on your individual situation. If you already have an infusion center, they can also let you know their availability of TEPEZZA.

To prepare for treatment with TEPEZZA, you may want to learn about the insurance approval process as well as what to expect when starting treatment. The resources below will help you get started.

Preparing for your first infusion

TEPEZZA is an IV (intravenous) medicine, which is delivered by infusion. You may receive TEPEZZA at your doctor’s office, a hospital, or an independent infusion center. An infusion center is a type of clinic that has advanced equipment and expert staff who specialize in giving infusions.

Learn more about infusions and how TEPEZZA is given

Your first and second TEPEZZA treatments may take up to 2 ½ hours. This includes time spent checking in, receiving your infusion, and being checked for any side effects afterwards. Infusions 3 through 8 may be shorter. These are just estimates and every patient is different. Your total time at the infusion center could be less or more.

To help you prepare for your first infusion, use the Before Infusion Reminder List:

Before Infusion Reminder List

To make the most out of your TEPEZZA treatment, all 8 infusions are recommended

In clinical studies with TEPEZZA, the majority of people who completed all 8 infusions had:

eye-bulging

Reduced eye bulging

double-vision

Improved double vision

eye-pain

Less eye pain, redness, and swelling

Physical appearance icon

Improved physical appearance and visual ability

Real results with TEPEZZA

Front view of proptosis before treatment

Before TEPEZZA

Front view of proptosis after TEPEZZA treatment

After Treatment (Week 24)

Real patient treated with TEPEZZA in a clinical study. Individual results may vary.

See more real before & after photos

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.