Starting Your Infusions

Use these tips to start and complete your treatment for Thyroid Eye Disease with confidence

Before starting TEPEZZA

There are some important things you and your doctor may want to do and discuss before your first infusion.

Pre-treatment eye exam icon

Pre-treatment eye exam

You’ve already had more than one eye exam for Thyroid Eye Disease (TED). But another exam just before you start treatment is important. It tells you and your doctor exactly how TED has affected your eyes so far. This will help you both keep track of any changes as you are treated with TEPEZZA.

Blood sugar icon

Blood sugar

Before you start TEPEZZA, talk with your doctor about having your blood sugar tested and tracked during treatment.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for blood sugar control as prescribed by your doctor.

Pregnancy icon

Pregnancy

TEPEZZA should not be used during pregnancy. Before you start TEPEZZA, tell your doctor if you are pregnant, suspect you are pregnant, or plan to become pregnant. TEPEZZA may harm your unborn baby. If you can become pregnant, you should use effective birth control (contraception) before you start TEPEZZA, while you’re being treated, and for at least 6 months after the final dose of TEPEZZA. Your doctor may want to perform a pregnancy test before you start TEPEZZA.

IBD icon

Inflammatory bowel disease

If you have inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. If you have IBD, your doctor may want to make sure it’s under control before you start treatment. Tell your doctor if any of your IBD symptoms get worse while you’re taking TEPEZZA.

Where to go for your TEPEZZA infusions

  • On the days you are treated with TEPEZZA, you may visit an infusion center
  • Infusion centers are outpatient clinics that specialize in giving intravenous, or “IV”, medicines. A trained medical professional will give you your TEPEZZA and will be with you for the whole process. This person is usually a registered nurse (RN), nurse practitioner (NP), or another medical professional
  • You may also receive TEPEZZA in a hospital or in your doctor’s office
  • Sometimes medicines like TEPEZZA can be given by a medical professional in your own home. Check with your doctor and your insurance provider to find out if home infusion is an option for you

Learn more about home infusion with TEPEZZA

  • If you are receiving infusions at home, learn how to store TEPEZZA

Home Storage Instructions

Preparing for your infusions

With steps such as checking in to your infusion center, getting your infusion, and being monitored for any side effects, your total time at the infusion center may take 2 to 2 1/2 hours.

Once you have gotten used to your infusion center, infusions 3 through 8 may be shorter. These are just estimates and every patient is different. Your total time at the infusion center could be less or more.

Here are a few things you can do before each infusion day to make sure you’re ready:

Confirm your appointment date, time, and address

If your doctor says you shouldn’t drive yourself, schedule rides to and from your appointment

Complete the Before Infusion Reminder List so you know you have all the details covered

Plan something special for yourself afterwards. You've earned it!

Watch Karen W., a real TEPEZZA patient, describe her first infusion experience

During your infusions

When it’s time to start your TEPEZZA treatment, you’ll be taken to an infusion chair, which is a lot like a recliner. Once the nurse has placed the IV in your arm, all you have to do is relax while you receive the medicine. For your first 2 infusions, you’ll be in the infusion chair for about 90 minutes. If your body reacts well to the treatment, the remaining 6 infusions may only last 60 minutes.

Here are a few tips on staying comfortable and at ease during your infusion:

  • Wear a shirt with sleeves that are easy to roll up
  • Bring a blanket or dress in layers. Infusion centers can be cold sometimes
  • Staying hydrated is important before and during your infusion. Pack a water bottle
  • Bring your favorite snack
  • Take a sleep mask or a pair of sunglasses in case the infusion center’s lights are bright

Passing the time

While you’re in the infusion chair, you may want to find ways to relax or make the most of your time. Here are a few ideas:

  • Meditation is a great way to unwind. Try apps such as Calm or Headspace for guided meditations. Just search for “Calm” or “Headspace” in your web browser or app store to learn more
  • You can also listen to music playlists on Spotify that feature soothing music and sounds. Go to Spotify and search for “Ambient Relaxation”, “Relax & Unwind”, or “Peaceful Piano”
  • Podcasts are another way to take your mind off your infusion and either inform or relax you

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TEPEZZA?

Infusion reactions can happen during or within 24 hours after your infusion of TEPEZZA. If you have a reaction while receiving TEPEZZA, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe infusion reaction, your doctor may stop your treatment completely.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with TEPEZZA:
  • High blood pressure
  • Fast heartbeat
  • Redness of the face/Feeling hot
  • Difficulty breathing
  • Headache
  • Muscle pain

If you have inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, TEPEZZA may make your IBD symptoms worse. Symptoms of worsening IBD may include: an increased number of loose stools with stomach pain or cramps, and blood in your stools. After each TEPEZZA infusion, tell your doctor right away if you have worsening IBD symptoms.

TEPEZZA may cause an increase in your blood sugar. Before starting treatment with TEPEZZA, tell your doctor if you are currently being treated for diabetes, know your blood sugar is high, or have been diagnosed with diabetes. It is important for you to take your treatments and follow an appropriate diet for glucose control as prescribed by your doctor.

Before receiving TEPEZZA, tell your doctor if you:
  • Have inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
  • Are currently being treated for diabetes, have been diagnosed with diabetes, or know your blood sugar is high.
  • Are pregnant or plan to become pregnant. TEPEZZA may harm your unborn baby. Tell your doctor if you become pregnant or suspect you are pregnant during treatment with TEPEZZA.
    • Women who are able to become pregnant should use an effective form of birth control (contraception) prior to starting treatment, during treatment and for at least 6 months after the final dose of TEPEZZA.
  • Are breastfeeding or plan to breastfeed. It is not known if TEPEZZA passes into your breast milk. Talk to your doctor about the best ways to feed your baby during treatment with TEPEZZA.
  • Tell your doctor about all the medicines you take, including prescription and over the counter medicines, vitamins, dietary and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What are the possible side effects of TEPEZZA?

The most common side effects of TEPEZZA include muscle cramps or spasms, nausea, hair loss, diarrhea, feeling tired, high blood sugar, hearing problems, taste changes, headache, and dry skin.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please visit TEPEZZA.com for more information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE

TEPEZZA is a prescription medicine used to treat Thyroid Eye Disease.